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Phenylalanine hydroxylase activity in hyperphenyl-alaninemia and classical phenylketonuria

Grimm, U.; Knapp, A.; Tischer, W.; Schlenzka, K.

Acta Biologica et Medica Germanica 28(3): 549-552

1972

ISSN/ISBN: 0001-5318
PMID: 5049643
Document Number: 51103
In a child with hyperphenylalaninaemia activity of phenylalanine hydroxylase in liver homogenate increased 5-fold when cofactor, 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropterin, was added. In 6 children with classical phenylketonuria values fell. In healthy persons values increased 35-fold when cofactor was added (Grimm et al., Acta Biologica et Medica Germanica (1971) 27, 443).

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