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Experimental research on the use of deferoxamine in the prevention of renal damage from acute ischemia

Libra, S.; Pagano, D.; Curella, G.; Litrico, V.; Cancelliere, M.; Audibert, D.; La Terra, S.; Gruttadauria, S.; Pappalardo, A.; D'Alessandro, M.

Annali Italiani di Chirurgia 70(4): 569-573

1999

ISSN/ISBN: 0003-469X
PMID: 10573619
Document Number: 510249
Oxygen free-radical reperfusion products play a critical role in postischemic tissues injury. In this study we used deferoxamine, an iron ligand that seems to inhibit hydroxyl radicals production, in renal normothermic acute ischemia in the rat. Our results demonstrated a significant protective effect of deferoxamine on kidneys subjected to normothermic acute ischemia.

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