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Inhibition of human breast cancer cell line BCap-37 by flavonoid extract of wheat germ in vitro

Xu, G.; Zhao, X.; Zhao, L.; Xu, H.

Wei Sheng Yan Jiu 28(3): 151-152

1999

ISSN/ISBN: 1000-8020
PMID: 12712718
Document Number: 510037
Cell growth and proliferation were measured by microculture tetrazolium(MTT) assay, cell colony-forming assay and the synthesis of DNA by 3H-thymidine incorporation. Flavonoid extract of wheat germ resulted to a dose-dependent, time-dependent growth inhibition, reduction of colony and 3H-thymiding incorporation in DNA of human breast cancer cell BCap-37. These findings indicated that the flavonoid extract of wheat germ can inhibit tumor cell growth and proliferation by blocking DNA synthesis in vitro.

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