Allopregnanolone attenuates kainate-induced toxicity in primary cortical neurons and PC12 neuronal cells
Kajta, M.; Budziszewska, B.; Lasoń, W.
Polish Journal of Pharmacology 51(6): 531-534
1999
ISSN/ISBN: 1230-6002 PMID: 10817532 Document Number: 509376
In this study, we demonstrated that allopregnanolone at 500 and 1000 nM significantly inhibited kainate-induced lactate dehydrogenase release from primary cortical cells by ca. 25 and 50%, respectively. Furthermore, allopregnanolone doses of 100 and 500 nM decreased cytotoxic effects of kainate (150 microM, 24-hour exposure) in PC12 neuronal cells by about 55 and 37%, respectively. These data strongly support neuroprotective effects of allopregnanolone observed in vivo.
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