The effect of Xuezhikang on oxidation of low-density lipoproteins in vitro
Xu, B.; Cheng, W.; Lu, X.
Zhonghua Nei Ke Za Zhi 38(8): 520-522
1999
ISSN/ISBN: 0578-1426 PMID: 11798688 Document Number: 509032
To study the effect of Xuezhikang on oxidation of human low-density lipoprotein. In vitro experiment was used to study the effect of Xuezhikang on the change of human low-density lipoprotein. Relative electrophoresis movement rate after oxidation of low-density lipoprotein mediated by addition of copper ion was observed. Oxidation of low-density lipoprotein mediated by copper ion was accelerated as the time of action prolonged and the process was accompanied by increased relative electrophoresis movement rate. Oxidation of low-density lipoprotein by copper ion was inhibited significantly in the presence of Xue zhikang as compared with absence of XuezhiKang at all time points. A greater reduction of reactive electrophoresis movement rate up to 33.5%, (P < 0.05) was noted. With increase of Xuezhikang concentration, the extent of reduction increased. It is shown that human low-density lipoprotein can be oxidized by mediation of copper ion and XuezhiKang may inhibit the extent of oxidation of low-density lipoprotein by copper ion.