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A gender gap in autoimmunity

Whitacre, C.C.; Reingold, S.C.; O'Looney, P.A.

Science 283(5406): 1277-1278

1999

ISSN/ISBN: 0036-8075
PMID: 10084932
Document Number: 508630
The U.S. National Multiple Sclerosis Society recently convened a special task force to investigate the underlying reasons for the sex differences in autoimmunity. Autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, and thyroiditis, tend to afflict a disproportionate amount of women compared to men. As a result, the task force decided on five aspects of these differences as priorities for future research: the distinct immune environments that exist in both sexes, the differing degree of immune response in men and women, the role of sex hormones in modulating susceptibility, disease differences during pregnancy, and genetic differences.

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