Severe hepatotoxicity caused by amiodarone: description of a case
Latorre, G.; Lucas, I.; Herrero, J.I.; Sangro, B.; Quiroga, J.; Sola, J.J.; Díaz, L.; Prieto, J.
Revista de Medicina de la Universidad de Navarra 43(2): 86-91
1999
ISSN/ISBN: 0556-6177 PMID: 11256009 Document Number: 508508
Amiodarone is useful for the treatment of ventricular and supraventricular arrhythmias, but it has been associated with several adverse effects. Amiodarone-induced hepatotoxicity is a frequent complication and often consist in a mild and asymptomatic elevation of liver function tests, although severe cases have been described. A case of severe amiodarone-induced hepatotoxicity slowly resolving after discontinuation of the drug and in which liver biopsy was crucial for diagnosis is reported. Although there are no pathognomonic histopathological findings, phospholipidosis is the morphologic hallmark of amiodarone hepatotoxicity.