Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity
Sotolongo, R.P.; Neefe, L.I.; Rudzki, C.; Ishak, K.G.
Gastroenterology 75(1): 95-99
1978
ISSN/ISBN: 0016-5085 PMID: 45581 Document Number: 130616
Sulfasalazine hepatotoxicity has been poorly documented in the literature. We report a case of a young female with inflammatory bowel disease who developed severe hepatotoxicity as part of a systemic hypersensitivity reaction to sulfasalazine. The clinical, biochemical, and histopathological features resemble those of sulfonamide-induced hepatic injury. Although rare, our case as well as previous reports indicate the serious nature of the illness.