The participation of glutaminergic transmission in the mechanism of movement disorders induced by reverse rotation in white mice
Lukomskaia, N.I.; Zhabko, E.P.; Gmiro, V.E.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 85(4): 497-501
1999
ISSN/ISBN: 0869-8139 PMID: 10513382 Document Number: 508167
Administration of MK-801 or IEM-1754 prevented akinesia in mice induced by reversing rotation, not less effectively than scopolamine. Quaternary adamantane derivative IEM-1857 was ineffective. IEM-1925 enhanced the locomotor disturbance induced by reversing rotation due, probably, to different spectrum of its antiglutamate action. The data obtained suggest involvement of glutamate synaptic transmission in development of locomotor disturbances of a vestibular origin.