Relationship of nitric oxide and immunal function of the patients with acute hepatitis and hepatic cirrhosis
Zhou, F.; Lu, F.; Wu, H.; Lin, Q.; Lin, L.
Hunan Yi Ke da Xue Xue Bao 24(4): 379-380
1999
ISSN/ISBN: 1000-5625 PMID: 12080655 Document Number: 507894
The interleukin-12(IL-12), interleukin-10(IL-10), tumor necrosis factor(TNF) and nitric oxide (NO) levels in serum of 90 patients with hepatitis and cirrhosis were measured by the method of ELISA and colorimeter. The levels of IL-12, IL-10 and NO in serum of the patients with hepatitis were in close proximity to the level of healthy control, but the TNF level was significantly higher than that of healthy control. The IL-12, IL-10, TNF and NO levels in serum of the patients of hepatic cirrhosis were significantly higher than that of healthy control and patients with hepatitis. The results suggested that the NO level was not related with the hepatic damage of acute hepatitis. The dysfunction of immunology in the patients with cirrhosis was related with the increase of NO level.