Top Abstract Purchase Related
Home
>
Node
>
Subnode

P53 gene of chang-liver cells (Atcc-Ccl13) exposed to aflatoxin B1 (Afb) : the effect of lysine on mutation at codon 249 of exon 7

Uwaifo, O.

African Journal of Medicine and Medical Sciences 28(1-2): 71-75

1999

ISSN/ISBN: 0309-3913
PMID: 12953991
Document Number: 507366
The effect of different regimes of lysine-pre treatment on mutation at the 3rd nucleotide base of codon 249 which is located at the 7th exon of p53 gene of Chang-liver cells (CCIL13) exposed to aflatoxin B1 (AFB1) has been investigated. There is an indication of inhibition of 1 ug/ml AFB1--induced mutation by pretreatment of cells for 72 hr with 5-molar fold lysine equivalent of 1 ug/ml AFB1 1 u/g ml AFB1 was the does at which there was 50% survival among the cells of CC13 in cytotoxicity studies. The results suggest chemo prevention of AFB1 induced mutation at codon 249 locus of Exon 7 in CCL13's p53 gene and by implication, maybe, AFB1-induced primary liver cancer.

Document emailed within 1 workday
Secure & encrypted payments

Il'inskaia, G.V.; Pugacheva, E.N.; Sokova, O.I.; Chumakov, P.M.; Kopnin, B.P. 1995: P53 with a mutation in codon 273 increases the probability of amplifying the dhfr gene in Rat-1 and LIM1215 cells Genetika 31(5): 611-616
Tanaka, A. 2006: Effect of Helicobacter pylori eradication on microsatellite instability and point mutation of K-ras codon 12 gene in intestinal metaplasia Hokkaido Journal of Medical Science 81(2): 111-120
Zhao, W.; Zhao, H.; Wang, K.; Zhang, W.; Wang, J. 2016: Cytotoxic effect of linear alkylbenzene sulfonate on human Chang liver cells Wei Sheng Yan Jiu 45(2): 263-267
Gussin, G.N.; Brown, S.; Matz, K. 1987: Translational polarity of a mutation in the initiator AUG codon of the lambda cI gene Genetics 117(2): 173-179
Cierniková, S.; Tomka, M.; Sedláková, O.; Reinerová, M.; Stevurková, V.; Kovác, M.; Cente, M.; Ilenciková, D.; Bella, V.; Zajac, V. 2003: The novel exon 11 mutation of BRCA1 gene in a high-risk family Neoplasma 50(6): 403-407
Orkin, S.H.; Kazazian, H.H.; Antonarakis, S.E.; Ostrer, H.; Goff, S.C.; Sexton, J.P. 1982: Abnormal RNA processing due to the exon mutation of beta E-globin gene Nature 300(5894): 768-769
Sitbon, G.; Hurtig, M.; Palotie, A.; Lönngren, J.; Syvänen, A.C. 1997: A colorimetric minisequencing assay for the mutation in codon 506 of the coagulation factor V gene Thrombosis and Haemostasis 77(4): 701-703
Takarada, Y.; Yamashita, K.; Ohtsuka, N.; Kagawa, S.; Matsuoka, A. 1993: Novel mutation in exon 7 of phenylalanine hydroxylase gene in a Chinese patient with phenylketonuria Clinical Chemistry 39(11 Part 1): 2357
Fan, Y.; Yu, L.; Jiang, Y.; Xu, Y.; Yang, R.; Han, Y.; Cui, Y.; Ren, M.; Zhao, S. 2000: Identification of a mutation hotspot in exon 8 of Wilson disease gene by cycle sequencing Chinese Medical Journal 113(2): 172-174
Tirawanchai, N.; Yamwong, P.; Pongrapeeporn, K.U.; Likidlilid, A.; Ong-Ajyooth, S.; Amornrattana, A. 2000: Screening for a D9N common mutation in exon 2 of the LPL gene in Thai normolipidemic and hyperlipidemic subjects Journal of the Medical Association of Thailand 83(Suppl 2): S54-S60
Yamwong, P.; Pongrapeeporn, K.U.; Thepsuriyanont, P.; Amornrattana, A.; Somkasettrin, A.; Sribhen, K. 2000: Mutation analysis of exon 9 of the LDL receptor gene in Thai subjects with primary hypercholesterolemia Journal of the Medical Association of Thailand 83(Suppl 2): S81-S88
Janssen, J.W.; Bartram, C.R. 1989: Silent mutation at codon 15 interferes with the detection of a mutated N-ras codon 12 allele by oligonucleotide hybridization Leukemia 3(3): 235
Jayo, A.; Pabón, D.; Lastres, P.; Jiménez-Yuste, V.; González-Manchón, C. 2006: Type II Glanzmann thrombasthenia in a compound heterozygote for the alpha IIb gene. A novel missense mutation in exon 27 Haematologica 91(10): 1352-1359
Meral, C.; Malbora, B.; Celikel, F.; Aydemir, G.ök.; Süleymanoğlu, S.; Zollino, M.; Derbent, M. 2012: A case of Mowat-Wilson syndrome caused by a truncating mutation within exon 8 of the ZEB2 gene Turkish Journal of Pediatrics 54(5): 523-527
Goldhammer, Y.; Gabizon, R.; Meiner, Z.; Sadeh, M. 1993: An Israeli family with Gerstmann-Sträussler-Scheinker disease manifesting the codon 102 mutation in the prion protein gene Neurology 43(12): 2718-2719
Xu, W.M.; Wang, Q.; Hua, X.Y. 1994: PCR-single-strand conformation (SSCP), DNA direct sequencing analysis in detecting mutation in exon 2 of g6pd gene Zhonghua Yi Xue Za Zhi 74(1): 35-37; 64
Pongrapeeporn, K.U.; Sutthikhum, V.; Likidlilid, A.; Poldee, S.; Futrakul, A.; Yamwong, P.; Amornrattana, A.; Ong-Ajyooth, S. 2000: Screening for mutations in exon 4 of the LDL receptor gene in Thai subjects with primary hypercholesterolemia: detection of a novel mutation D151Y by PCR-CFLP Journal of the Medical Association of Thailand 83(Suppl 2): S66-S73
Defesche, J.C.; Lansberg, P.J.; Reymer, P.W.; Lamping, R.J.; Kastelein, J.J. 1993: Analysis of the Afrikaner mutation in exon 9 of the low-density lipoprotein receptor gene in a large Dutch kindred suffering from familial hypercholesterolaemia Netherlands Journal of Medicine 42(1-2): 53-60
Weiss, B.; Hui, K.S.; Hui, M.; Lajtha, A. 1983: Effect of bestatin analogues and other compounds on enkephalin hydrolysis by an aminopeptidase from the mesophiles pseudomonas sp ATCC 11299A and chromobacterium violaceum ATCC 12540 Research Communications in Chemical Pathology and Pharmacology 39(3): 463-475
Guida, S.; Giglioni, B.; Comi, P.; Ottolenghi, S.; Camaschella, C.; Saglio, G. 1984: The beta-globin gene in Sardinian delta beta 0-thalassemia carries a C----T nonsense mutation at codon 39 EMBO Journal 3(4): 785-787