Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia
Staff, A.C.; Halvorsen, B.; Ranheim, T.; Henriksen, T.
American Journal of Obstetrics and Gynecology 181(5 Pt 1): 1211-1215
1999
ISSN/ISBN: 0002-9378 PMID: 10561647 Document Number: 506674
OBJECTIVES: The prostaglandinlike compound 8-iso-prostaglandin F2alpha represents an index of oxidative stress and has the ability to induce endothelial derangement, platelet activation, and vasoconstriction. In women with preeclampsia the decidual spiral arteries contain lipid deposits (acute atherosis). Analogously to the elevated level of 8-iso-prostaglandin F2alpha demonstrated in atherosclerotic lesions, we hypothesized that 8-iso-prostaglandin F2alpha level would be elevated in preeclamptic decidua basalis tissues. STUDY DESIGN: Decidua basalis tissues were obtained by vacuum aspiration and placental tissues were obtained by excision at cesarean delivery from 16 preeclamptic and 15 normal pregnancies. Total and free 8-iso-prostaglandin F2alpha concentrations were quantified with an enzyme immunoassay technique after lipid extraction and separation. RESULTS: The content of free 8-iso-prostaglandin F2alpha in preeclamptic decidual tissues was found to be significantly elevated with respect to that in control tissues. The content of total 8-iso-prostaglandin F2alpha did not differ significantly between the groups in either placenta or decidua basalis. CONCLUSIONS: We propose that free 8-iso-prostaglandin F2alpha released from the decidua basalis in preeclampsia may mediate maternal vascular dysfunction and platelet activation.