Effects of short-course buserelin therapy on adenomyosis. A report of two cases
Huang, F.J.; Kung, F.T.; Chang, S.Y.; Hsu, T.Y.
Journal of Reproductive Medicine 44(8): 741-744
1999
ISSN/ISBN: 0024-7758 PMID: 10483548 Document Number: 506329
BACKGROUND: Hysterectomy and hysteroscopic endometrial ablation remain common treatment of symptomatic adenomyosis for women who have completed child-bearing. However, for patients who wish to avoid surgery and in whom adenomyosis is suspected of causing infertility, repeated abortion or physical symptoms, medical treatment with gonadotropin-releasing hormone analogue (GnRH-a) should be considered. CASES: Two cases of documented adenomyosis were suspected of causing infertility; both were treated with a three-month course of GnRH-a via a nasal spray. Both patients experienced relief of symptoms and conceived within six months of the cessation of treatment. CONCLUSION: The efficacy and safety of a short course of GnRH-a treatment of adenomyosis may be considered in patients who take less time than others to achieve a significant reduction of uterine size and relief of symptoms and in those who develop side effects.