Gap junctional intercellular communication and carcinogenesis
Sulkowski, S.; Sulkowska, M.; Skrzydlewska, E.
Polish Journal of Pathology Official Journal of the Polish Society of Pathologists 50(4): 227-233
1999
ISSN/ISBN: 1233-9687 PMID: 10721262 Document Number: 506235
Intercellular communications are indispensable for the maintenance of homeostasis in the multicellular organisms. Gap-type junctions are one of the most common and perhaps most interesting intercellular connections. Of various communication systems gap junctional intercellular communication is the only means for cells to directly exchange signals. Substantial progress has recently been made in the studies on the role of gap junctions both in experimental and human tumorigenesis. The present study is a review of the potential mechanisms associated with gap junctional cellular communication included in non-genotoxic tumorigenesis.