CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers
Dinsdale, J.R.; Griffiths, G.K.; Castelló, J.; Maddock, J.; Ortiz, J.A.; Aylward, M.
Arzneimittel-Forschung 33(7a): 1061-1065
1983
ISSN/ISBN: 0004-4172 PMID: 6684468 Document Number: 5051
Cytidine diphosphate choline (CDP-choline, citicoline, Somazina) was administered to 12 adult healthy volunteer subjects in two short-term chronic oral dose regimens (600 mg X day-1 and 1g X day-1), each of 5 consecutive days, and compared with a corresponding regimen of matched placebo. Transient headaches were the only untoward events recorded, occurring in 4 and 5 subjects, respectively, on the lower and higher dose regimens but in only one subject during placebo administration.
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