Effect of ethynodiol diacetate and combination--type oral contraceptive compounds on carbohydrate metabolism. I. Six month intravenous glucose tolerance study
Goldman, J.A.
Diabetologia 11(1): 45-48
1975
ISSN/ISBN: 0012-186X PMID: 1140518 DOI: 10.1007/bf00422817Document Number: 504864
The effects of ethynodiol diacetate (.5 mg) and Enovid (5 mg norethynodrel with .075 mg mestranol) on blood glucose and plasma insulin levels were studied in 36 normal women. Each patient was studied before and after a 6-month treatment period. Mean glucose and plasma values before and after ethynodiol diacetate treatment did not differ significantly. Mean glucose values were significantly different at 15 minutes, 30 minutes, and 120 minutes of the test in women taking Enovid (p less than .01, p less than .01, and p less than .05, respectively). Mean plasma insulin values were also significantly different at 60 minutes of the test after Enovid therapy (p less than .02). The results suggest that oral contraceptives containing estrogen-progesterone in combination possess a diabetogenic effect, whereas ethynodiol diacetate has no hyperglycemic effect.
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