Ethynodiol diacetate as a contraceptive
Rúiz-Velasco, V.; Ortiz Mariscal, J.D.; Salgado, H.J.; Salinas, G.R.; Zelaya, A.P.; Partida, J.B.
Fertility and Sterility 25(11): 927-934
1974
ISSN/ISBN: 0015-0282 PMID: 4426405 DOI: 10.1016/s0015-0282(16)40750-8Document Number: 503770
437 multiparous women were given ethynodiol diacetate in continuous microdoses of .35 mg/day, .50 mg/day, .25 mg/twice a day, or .125 mg/twi ce a day. 7 pregnancies occurred during treatment, 5 due to medication failure; 2 were in the .5 mg/day group and 3 were in the .125 mg/twice a day group. Women taking .5 mg/day and .25 mg/twice a day had most menstrual irregularities (10% of the cycles). Side effects noted were: headache, nervousness, nausea and vomiting, and abdominal pain. Most of the patients lost weight; lactation did not appear to be affected by the medication. Uterine tone changed during treatment; there was a decrease in frequency, an increase in intensity and an increase in the tone of the contractions. It is concluded that the contraceptive efficacy was directly related to dosage as were menstrual and uterin disturbances, except for side effects. Ovulation was not inhibited although contraception was produced.