Top Abstract Purchase Related
Home
>
Node
>
Subnode

Thrombosis induced by homocysteine does not depend on platelet aggregation or heparin cofactor's antithrombin activity

Zhang, L.; Zhang, G.

Hunan Yi Ke da Xue Xue Bao 24(4): 309

1999

ISSN/ISBN: 1000-5625
PMID: 12080632
Document Number: 504631
To partly elucidate the relationship between homocysteine(Hcy) and thrombosis, we observed Hcy's effects on platelet aggregation and antithrombin activity of heparin cofactor in vitro. Platelet aggregation assay and chromogenic assay were used in this research. Homocysteine had no effects on platelet aggregation induced by ADP and thrombin or heparin cofactor's antithrombin activity in vitro (P > 0.05). There is no correlation between Hcy and the "ADP passway" of platelet aggregation. Thrombosis induced by Hcy does not depend on heparin cofactor's antithrombin activity either.

Document emailed within 1 workday
Secure & encrypted payments

White, M.M.; Siders, L.; Jennings, L.K.; White, F.L. 1992: The effect of residual heparin on the interpretation of heparin-induced platelet aggregation in the diagnosis of heparin-associated thrombocytopenia Thrombosis and Haemostasis 68(1): 88
Chong, B.H.; Pitney, W.R.; Castaldi, P.A. 1982: Heparin-induced thrombocytopenia: association of thrombotic complications with heparin-dependent IgG antibody that induces thromboxane synthesis in platelet aggregation Lancet 2(8310): 1246-1249
Kondo, S.; Niwa, M. 1985: Antithrombin IIi and heparin cofactor Ii Rinsho Byori. Japanese Journal of Clinical Pathology Spec no 61: 106-113
Scully, M.F.; Ellis, V.; Kakkar, V.V. 1986: Pentosan polysulphate: activation of heparin cofactor II or antithrombin III according to molecular weight fractionation Thrombosis Research 41(4): 489-499
Lopaciuk, S.; Bykowska, K.; Kopeć, M. 1996: Prevalence of heparin cofactor Ii deficiency in patients with a history of venous thrombosis Polish Journal of Pharmacology 48(1): 109-111
Fuse, I.; Hattori, A.; Mito, M.; Higuchi, W.; Yahata, K.; Shibata, A.; Aizawa, Y. 1996: Pathogenetic analysis of five cases with a platelet disorder characterized by the absence of thromboxane A2 (TXA2)-induced platelet aggregation in spite of normal TXA2 binding activity Thrombosis and Haemostasis 76(6): 1080-1085
Gouault-Heilmann, M.; Contant, G.; Pochmalicki, G.; Jan, F. 1984: Disseminated intravascular coagulation induced by heparin. Treatment with a combination of low-molecular weight heparin and concentrated antithrombin IIi Presse Medicale 13(22): 1393-1394
Iioka, H.; Hisanaga, H.; Moriyama, I.; Akasaki, M.; Nabuchi, K.; Katakami, Y.; Katoh, Y.; Ichijo, M. 1989: The study on the platelet aggregation inhibition activity of placental brush border (the mechanism of platelet aggregation inhibition) Nihon Sanka Fujinka Gakkai Zasshi 41(12): 1916-1920
Akai, Y.; Shiga, S.; Tohyama, K.; Shimatsu, A.; Ichiyama, S. 2000: Effect of heparin cofactor Ii on the antithrombin IIi activities measured by thrombin methods or factor Xa methods--fundamental studies and clinical studies using the plasma of pregnant women Rinsho Byori. Japanese Journal of Clinical Pathology 48(9): 867-871
Armstrong, R.; May, J.A.; Lösche, W.; Heptinstall, S. 1995: Factors that contribute to spontaneous platelet aggregation and streptokinase-induced aggregation in whole blood Thrombosis and Haemostasis 73(2): 297-303
Haskel, E.J.; Agarwal, K.C.; Parks, R.E. 1980: ATP- and ADP-induced rat platelet aggregation: significance of plasma in ATP-induced aggregation Thrombosis and Haemostasis 42(5): 1580-1588
Francis, C.W.; Pellegrini, V.D.; Marder, V.J.; Harris, C.M.; Totterman, S.; Gabriel, K.R.; Baughman, D.J.; Roemer, S.; Burke, J.; Goodman, T.L. 1989: Prevention of venous thrombosis after total hip arthroplasty. Antithrombin III and low-dose heparin compared with dextran 40 Journal of Bone and Joint Surgery. American Volume 71(3): 327-335
Shiba, T.; Takeuchi, S.; Awazu, S.; Igarashi, M.; Asada, T. 1978: Antiocoagulant activity of chondroitin sulfate A, B and C.--co-operative action with heparin cofactor Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 41(3): 560-563
Francis, C.W.; Pellegrini, V.D.; Stulberg, B.N.; Miller, M.L.; Totterman, S.; Marder, V.J. 1990: Prevention of venous thrombosis after total knee arthroplasty. Comparison of antithrombin III and low-dose heparin with dextran Journal of Bone and Joint Surgery. American Volume 72(7): 976-982
Stulberg, B.N.; Francis, C.W.; Pellegrini, V.D.; Miller, M.L.; Shull, S.; deSwart, R.; Easley, K.; Totterman, S.; Marder, V.J. 1989: Antithrombin III/low-dose heparin in the prevention of deep-vein thrombosis after total knee arthroplasty. A preliminary report Clinical orthopaedics and related research 1989(248): 152-157
Davies, J.A.; Menys, V.C. 1982: Effect of heparin on platelet monolayer adhesion, aggregation and production of malondialdehyde Thrombosis Research 26(1): 31-41
Yi, F.X.; Guo, Z.G. 1998: Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium Zhongguo Yao Li Xue Bao 19(4): 379-382
Appel, J.Z.; Alwayn, I.P.; Correa, L.E.; Cooper, D.K.; Robson, S.C. 2001: Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. II. The effects of cyclophosphamide on pig peripheral blood progenitor cell-induced aggregation Transplantation 72(7): 1306-1310
Rossi, E.C.; Louis, G.; Bieber, M.; Zeller, E.A. 1978: Platelet monoamine oxidase and epinephrine-induced platelet aggregation Thrombosis and Haemostasis 40(1): 37-42
Nakagawa, M.; Okada, T.; Okuda, S.; Nishizawa, A.; Watada, M. 1977: Exogenous heparin and antithrombin activity Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 40(2): 207-212