Structural regularities in activated cleavage sites of thrombin receptors
Mikhaĭlik, I.V.; Verevka, S.V.
Ukrains'kyi Biokhimichnyi Zhurnal 71(6): 111-112
1999
ISSN/ISBN: 0372-3909 PMID: 10820858 Document Number: 504359
Comparison of thrombin receptors activation splitting sites sequences testifies to their similarity both in activation splitting sites of protein precursors and protein proteinase inhibitors reactive sites. In all these sites corresponded to effectory sites P2'-positions are placed by hydrophobic amino-acids only. The regularity defined conforms with previous thesis about the role of effectory S2'-site in regulation of the processes mediated by serine proteinases.