Formation and characteristics of an artificial dermis--collagen-chondroitin-6-sulfate membrane
Li, X.; Shi, J.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 16(2): 151-153
1999
ISSN/ISBN: 1001-5515 PMID: 12552652 Document Number: 503862
In this study, we extracted type-I collagen from rat tail tendon with acetic acid and then mixed it with chondroitin-6-sulfate to form a collagen-chondroitin-6-sulfate membrane by freeze drying and crosslinking. The result showed that the collagen-chondroitin-6-sulfate membrane was semitransparent, with a network structure, and the pore size was about 100-150 microns. It was also demonstrated that the "dermis" achieved a good adherence to wound and the degradation rate in vitro was markedly decreased by glutaraldehyde crosslinkage.