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Nitric oxide in interstitial nephritis and other autoimmune diseases

Kelly, C.J.; Gold, D.P.

Seminars in Nephrology 19(3): 288-295

1999

ISSN/ISBN: 0270-9295
PMID: 10226335
Document Number: 503857
Nitric oxide can be generated by macrophages, as well as many other cell types, through a cytokine inducible isoform of nitric oxide synthase. Historically the effector functions ascribed to iNOS-generated NO have been the control of intracellular organisms and tumor cell cytotoxicity. However, there is a growing appreciation that iNOS generated NO can additionally play an important role in immunoregulation. In this review, the authors outline the effects of iNOS inhibition or genetic deletion on the expression of several autoimmune diseases and discuss potential mechanisms underlying the immunosuppressive effects of NO.

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