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The possible role of loss of heterozygosity at APC, MCC and DCC genetic loci in esophageal carcinoma

Wang, M.; Lu, R.; Fang, D.

Zhonghua Zhong Liu Za Zhi 21(1): 16-18

1999

ISSN/ISBN: 0253-3766
PMID: 11776787
Document Number: 503700
To investigate the alterations of APC, MCC and DCC genes in human esophageal carcinoma. A total of 46 human esophageal cancer specimens were analyzed for the loss of heterozygosity (LOH) at APC, MCC and DCC genetic loci by means of polymerase chain reaction and restriction fragment length polymorphism. The incidence of LOH was 29.0%(9/31) at APC locus, 33.3%(8/24) at MCC locus, and 32.4%(12/37) at DCC locus, respectively. However, there was no statistically significant correlation between LOH at these three loci with such clinical parameters as pathological types, tumor size, invasiveness, and lymph-node metastasis. These data suggest that LOH at APC, MCC and DCC loci in esophageal carcinoma is, to certain extent, a common genetic alteration which might play a role in esophageal carcinogenesis.

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