Top Abstract Purchase Related
Home
>
Node
>
Subnode

Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas

Simon, D.; Knowles, B.B.; Weith, A.

Oncogene 6(5): 765-770

1991

ISSN/ISBN: 0950-9232
PMID: 1646986
Document Number: 373399
Cytogenetic analysis of eight human hepatoma-derived cell lines and one primary hepatocellular carcinoma biopsy revealed multiple chromosome abnormalities; however, only chromosome 1 was consistently affected by rearrangements. Pseudopolysomy 1 as well as chromosome 1 deletions and/or translocations that resulted in loss of the distal 1p region from at least one copy of chromosome 1 were observed in all but one of the cell lines analysed. Molecular analyses of tumor-derived and normal genomic DNA from six cases of hepatocellular carcinoma and from two of hepatoblastoma, using a panel of chromosome 1p-specific DNA probes indicated allelic loss in the distal 1p region in five of the six hepatocellular carcinomas but not in either hepatoblastoma. These results suggest the location of a gene in the distal 1p region whose functional loss may be involved in hepatocellular carcinogenesis.

Document emailed within 1 workday
Secure & encrypted payments

Suzuki, T.; Yokota, J.; Mugishima, H.; Okabe, I.; Ookuni, M.; Sugimura, T.; Terada, M. 1989: Frequent loss of heterozygosity on chromosome 14q in neuroblastoma Cancer Research 49(5): 1095-1098
Maestro de las Casas, M.L.; del Barco Barriuso, V.; Moreno Sierra, J.; Izquierdo López, L.; Sanz Casla, M.T.; Zanna, I.; Redondo González, E.; Chicharro Almarza, J.; Fernández Pérez, C.; Resel Estévez, L. 1999: The loss of heterozygosity on the short arm of chromosome 3 in renal carcinoma Archivos Espanoles de Urologia 52(1): 3-9
Li, X.; Ding, M.; Lai, B. 2001: Frequent loss of heterozygosity on chromosome 4 in human hepatocellular carcinoma Zhonghua Yi Xue Za Zhi 81(1): 37-40
Yokota, J.; Tsukada, Y.; Nakajima, T.; Gotoh, M.; Shimosato, Y.; Mori, N.; Tsunokawa, Y.; Sugimura, T.; Terada, M. 1989: Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix Cancer Research 49(13): 3598-3601
Millikin, D.; Meese, E.; Vogelstein, B.; Witkowski, C.; Trent, J. 1991: Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma Cancer Research 51(20): 5449-5453
Young, J.; Leggett, B.; Ward, M.; Thomas, L.; Buttenshaw, R.; Searle, J.; Chenevix-Trench, G. 1993: Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas Oncogene 8(3): 671-675
Gao, X.; Zacharek, A.; Salkowski, A.; Grignon, D.J.; Sakr, W.; Porter, A.T.; Honn, K.V. 1995: Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer Cancer Research 55(5): 1002-1005
Rasio, D.; Negrini, M.; Manenti, G.; Dragani, T.A.; Croce, C.M. 1995: Loss of heterozygosity at chromosome 11q in lung adenocarcinoma: identification of three independent regions Cancer Research 55(18): 3988-3991
Wertheim, I.; Tangir, J.; Muto, M.G.; Welch, W.R.; Berkowitz, R.S.; Chen, W.Y.; Mok, S.C. 1996: Loss of heterozygosity of chromosome 17 in human borderline and invasive epithelial ovarian tumors Oncogene 12(10): 2147-2153
Adamson, R.; Jones, A.S.; Field, J.K. 1994: Loss of heterozygosity studies on chromosome 17 in head and neck cancer using microsatellite markers Oncogene 9(7): 2077-2082
Xu, S.-f.; Li, D.-p.; Peng, Z.-h. 2008: Refined mapping of heterozygosity loss on chromosome 5p15 in sporadic colorectal cancer Zhonghua Zhong Liu Za Zhi 30(6): 413-417
Xiao, Z.; Zhang, J.; Zheng, S.; Li, C.; He, Z.; Cheng, S.; Gao, Y. 2002: Loss of heterozygosity of tumor suppressor genes at chromosome 3p in transitional cell carcinoma of urinary bladder Zhonghua Yi Xue Za Zhi 82(20): 1375-1377
Mathew, S.; Murty, V.V.; Bosl, G.J.; Chaganti, R.S. 1994: Loss of heterozygosity identifies multiple sites of allelic deletions on chromosome 1 in human male germ cell tumors Cancer Research 54(23): 6265-6269
Lee, W.C.; Balsara, B.; Liu, Z.; Jhanwar, S.C.; Testa, J.R. 1996: Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma Cancer Research 56(19): 4297-4301
Kanno, H.; Shuin, T.; Kondo, K.; Yamamoto, I.; Ito, S.; Shinonaga, M.; Yoshida, M.; Yao, M. 1997: Somatic mutations of the von Hippel-Lindau tumor suppressor gene and loss of heterozygosity on chromosome 3p in human glial tumors Cancer Research 57(6): 1035-1038
Miyoshi, Y. 2012: Loss of heterozygosity (LOH) at BRCA1 loci in primary breast cancers Nihon Rinsho. Japanese Journal of Clinical Medicine 70(Suppl 7): 174-179
Emi, M.; Fujiwara, Y.; Nakajima, T.; Tsuchiya, E.; Tsuda, H.; Hirohashi, S.; Maeda, Y.; Tsuruta, K.; Miyaki, M.; Nakamura, Y. 1992: Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer Cancer Research 52(19): 5368-5372
Zenklusen, J.C.; Thompson, J.C.; Troncoso, P.; Kagan, J.; Conti, C.J. 1994: Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1 Cancer Research 54(24): 6370-6373
Panani, A.D.; Pappa, V. 2005: Hidden chromosome 8 abnormalities detected by FISH in adult primary myelodysplastic syndromes In Vivo 19(6): 979-981
Jonveaux, P.; Dachary, D.; Marit, G.; Wen, Z.; Lacombe, F.; Groulier, J.L.; Reiffers, J.; Broustet, A.; Bernard, P. 1986: Acute myelomonocytic leukemia with bone marrow hypereosinophilia and chromosome 16 inversion. Primary or secondary chromosomal abnormalities? Presse Medicale 15(40): 2022