Prolactin secretion in sixty-five patients with galactorrhea
Tolis, G.; Somma, M.; Van Campenhout, J.; Friesen, H.
American Journal of Obstetrics and Gynecology 118(1): 91-101
1974
ISSN/ISBN: 0002-9378 PMID: 4202979 DOI: 10.1016/s0002-9378(16)33651-1Document Number: 503604
These patients included groups with non-functioning hypothalamic-pituitary tumours, prolactin-secreting tumours, acromegaly, Chiari-Frommel syndrome, Argonz-del Castillo syndrome, history of phenothiazine or alpha -methyl-DOPA intake, primary hypothyroidism, idiopathic galactorrhoea and those using contraceptive medication. Serum prolactin concn. were determined by radioimmunoassay and were found to be significantly (P < 0.001) higher (100-1000 ng/ml) in the group with prolactin-secreting pituitary tumours associated with amenorrhoea. In all groups there was no correlation between serum prolactin levels and degree of galactorrhoea. Neither the demonstration of a single elevated serum prolactin level nor the degree of suppressibility after L-DOPA administration was diagnostic of a pituitary tumour. However, a history of consistently high serum prolactin concn. was highly indicative of a prolactin-secreting tumour.
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