Adult respiratory distress syndrome-like disorders after allogeneic bone marrow transplantation
Takatsuka, H.; Takemoto, Y.; Okamoto, T.; Fujimori, Y.; Tamura, S.; Wada, H.; Okada, M.; Kanamaru, A.; Kakishita, E.
Transplantation 68(9): 1343-1347
1999
ISSN/ISBN: 0041-1337 PMID: 10573074 Document Number: 503515
Background. Adult respiratory distress syndrome-like respiratory disorders are a serious, but uncommon, complication of bone marrow transplantation. Methods. We measured various cytokines in 2 patients with respiratory disorders and 11 patients without respiratory problems after allogeneic bone marrow transplantation. Results. The patients with respiratory disorders had elevated levels of interferon-gamma and interleukin-2 in the aplastic phase, and elevation of tumor necrosis factor-alpha, intercellular adhesion molecule-1, and interleukin-8 at the time of leukocyte recovery. Both patients with respiratory disorders developed fever during the aplastic phase, whereas none of the patients without fever had respiratory disorders. Among patients who had fever during the aplastic phase but no respiratory disorders, there was no elevation of cytokines from the aplastic phase to the recovery phase. Conclusions. Respiratory disorders may occur after bone marrow transplantation when an inflammatory response during the aplastic phase stimulates cytokines that cause vascular endothelial damage and increases the levels of chemokines and adhesive molecules along with elevation of the leukocyte count.