Allogeneic marrow transplantation in severe bone marrow aplasia. Factors determining the outcome in a series of 27 consecutive cases
Rozman, C.; Grañena, A.; Marín, P.; Hernández-Prieto, M.; Nomdedeu, B.; Montserrat, E.; Feliu, E.; Bladé, J.; Cervantes, F.; Vives Corrons, J.L.
Medicina Clinica 84(4): 129-134
1985
ISSN/ISBN: 0025-7753 PMID: 3884918 Document Number: 263052
The experience with 29 consecutive allogenic bone marrow transplants (TMO) performed in 27 patients with severe bone marrow aplasia are described. Survival rates show a plateau at 32% with 9 patients alive between 13 mo. and 6.5 yr after the TMO. The survival rate in the last 13 patients is 46%. Among the important factors determining the outcome the following must be noted: age (worse prognosis after age 30, P < 0.05), number of pre-TMO transfusions (70% survival rates in patients with < 10 transfusions, P < 0.025), plasmapheresis pre-TMO (worse prognosis if performed, P < 0.005), sex donor-recipient (better prognosis if identical, P < 0.025), number of cells given (> 71.5% survival if > 3.0 .times. 108/kg, P < 0.001), and graft vs. host disease (EICH) (worse if present in its severe form, P < 0.005). Multivariate analysis of survival rates permitted the isolation of the following 5 most important variables: hematological reconstitution, EICH, plasmapheresis, donor-recipient sex and number of cells administered. The multivariate analysis of the factors conditioning a complete hematological reconstitution permitted also to identify as the most important factors the identical sex of donor-recipient and the period transcurred from the diagnosis of aplasia until the TMO.