Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine
Dun, W.; Zhao, R.R.; Li, J.G.; Wu, B.W.
Zhongguo Yao Li Xue Bao 20(6): 525-528
1999
ISSN/ISBN: 0253-9756 PMID: 10678146 Document Number: 503387
To study the effects of propylbutyldopamine (PBDA) on the inward rectifier potassium current (Ik1). The quasi-steady state current-voltage relationship from the isolated guinea pig ventricular cells were measured using whole-cell patch-clamp techniques with a slow ramp depolarization (8 mV.s-1). PBDA 5, 50, and 100 mumol.L-1 concentration-dependently reduced the inward rectifier potassium current. PBDA blocked Ik1 in guinea pig ventricular cells. The effect of PBDA was not blocked by the selective dopamine D2-receptor blocker, domperidone. PBDA inhibited Ik1 directly, independent of the dopamine D2-receptor.