Inhibition of sodium-potassium-activated adenosine 5'-triphosphatase and ion transport by adriamycin
Gosálvez, M.; van Rossum, G.D.; Blanco, M.F.
Cancer Research 39(1): 257-261
1979
ISSN/ISBN: 0008-5472 PMID: 216483 Document Number: 153600
The antitumor antibiotic Adriamycin is a potent inhibitor of the sodium-potassium-activated adenosine triphosphatase of native heart microsomes. Adriamycin also inhibits potassium transport (although not sodium transport) in slices of kidney cortex. The effects on both the adenosine triphosphatase and ion transport are markedly reduced by Ca2+, probably by chelation of this metal by Adriamycin. These effects could provide a basis for explaining the Adriamycin cardiotoxicity as a digitalis-type toxicity.