Subtypes of central nicotinic receptors involved in learning and memory
Chen, L.J.; Chen, R.Z.
Zhongguo Yao Li Xue Bao 20(8): 725-728
1999
ISSN/ISBN: 0253-9756 PMID: 10678106 Document Number: 501294
To observe the effects of different subtypes of central nicotinic receptor on learning and memory. Passive avoidance response, including step-down avoidance and step-through avoidance in mice and long-term potentiation (LTP) in rat hippocampal slices. Hexamethonium (C6) 7 micrograms/mouse and kappa-bungarotoxin (kappa-BTX) 0.6 microgram/mouse inhibited the acquisition of avoidance conditioning in mice, and kappa-BTX yielded this effect with a dose-response relationship. kappa-BTX 1 mumol.L-1 suppressed the induction of LTP (P < 0.05), but not normal synaptic transmission and maintenance of LTP in rat hippocampal slices. The subtypes of central nicotinic receptor sensitive to kappa-BTX play an important role in learning and memory.