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Kinetic properties of nicotinic receptors in cultured rat sympathetic neurons from superior cervical ganglia

Zheng, J.Q.; He, X.P.; Yang, A.Z.; Liu, C.G.

Zhongguo Yao Li Xue Bao 18(4): 330-333

1997

ISSN/ISBN: 0253-9756
PMID: 10072915
Document Number: 483292
AIM: To analyze the kinetic properties of the effect of nicotine on nicotinic acetylcholine receptors (nAChR) in the cultured sympathetic neurons from neonatal rat superior cervical ganglia (SCG). METHODS: The whole-cell recording method of patch-clamp technique was used to record the currents induced by different concentrations of nicotine. The concentration-response of nicotine was fitted with Clark equation. RESULTS: Hill coefficient (1.097) was determined by fitting the nicotine responses of neuronal nAChR with Clark equation. The theoretical values of nicotine effect, calculated with Clark equation with H = 1, were basically identical with the practically recorded currents. CONCLUSIONS: Interaction of nicotine and nAChR in rat SCG fits a single binding site model.

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