Division of Medicinal Chemistry--endothelins
Agathangelou, P.
Idrugs the Investigational Drugs Journal 2(6): 515-516
1999
ISSN/ISBN: 1369-7056 PMID: 16127603 Document Number: 501172
The endothelins are a family of three potent vasoactive peptides, ET-1, -2 and -3, which comprise 21 amino acids and contain two disulfide bridges between cysteine residues. They were originally isolated from human vascular endothelial cells. Two endothelin receptor subtypes, A and B (ETA and ETB, respectively) have also been identified, although their function still requires further clarification. A brief overview of this field, particularly in terms of the pharmacology and physiology of endothelins, was given by a number of the speakers, who also focused on the recent developments and discoveries within their own projects.