Adaptive resistance of Saccharomyces cerevisiae to chronic treatment with genotoxic and nongenotoxic carcinogens
Fahrig, R.; Fahrig, B.
Journal of Environmental Pathology Toxicology and Oncology Official Organ of the International Society for Environmental Toxicology and Cancer 18(2): 103-108
1999
ISSN/ISBN: 0731-8898 PMID: 15281221 Document Number: 500584
The exposure of mammalian cells or tumors for weeks or months to low nonlethal doses of cytostatic drugs may induce multidrug resistance, which can be enhanced by a variety of DNA-damaging agents. Multidrug resistance to a variety of drugs has been observed. But in yeast, DNA-damaging agents have not yet been tested. As the appearance of resistance is the result of longterm exposure, we decided to extend the application of test substances to a period of up to 400 days. In such long-term experiments S. cerevisiae MP1 adapted to treatment with low doses of mutagens. Consistent results were obtained for both genotoxic and nongenotoxic carcinogenic substances, which implies that there may be a single pathway for carcinogens with different modes of action.