Bone non-union after osteotomy in patients treated with methotrexate
Gerster, J.C.; Bossy, R.; Dudler, J.
Journal of Rheumatology 26(12): 2695-2697
1999
ISSN/ISBN: 0315-162X PMID: 10606386 Document Number: 500213
We describe 2 men with seronegative rheumatoid arthritis who presented non-union of bone after osteotomy of the tibia in one case and of a metatarsal bone in the second. Both patients were still being treated with oral low doses of methotrexate (MTX). After MTX was stopped, a prompt healing of the bone occurred. These observations suggest that MTX should be stopped temporarily in cases with delayed bone healing after surgery.
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