The same genetic regions encode minor histocompatibility antigens detected in the context of different MHC haplotypes
Klinge, H.; Roopenian, D.C.
Transplantation 67(8): 1178-1183
1999
ISSN/ISBN: 0041-1337 PMID: 10232571 Document Number: 499321
The mammalian genome encodes numerous autosomal minor histocompatibility (H) antigens that act as a barrier to allogeneic tissue transplantation when donor and recipient are matched for the major histocompatibility complex (MHC). However, most of our understanding of the genetic basis of such minor H antigens is limited to analysis of mouse strains of the H2b haplotype. To broaden our understanding, we investigated minor H antigens detected in the context of other MHC alleles. As measured by graft survival and precursor cytotoxic T lymphocytes from blood, our results suggest that chromosomal segments known to encode minor H antigens detected in the context of the H2b haplotype are antigenically complex in that they also frequently encode minor H antigens that can be detected in the context of at least the H2d and H2k haplotypes. Genetic models to account for this complexity are discussed.