Experimental investigation of 2,2'-diamino-1,1'-dinaphthyl in rats and mice
Zabezhinskiĭ, M.A.; Pliss, G.B.
Voprosy Onkologii 45(4): 434-437
1999
ISSN/ISBN: 0507-3758 PMID: 10532106 Document Number: 498001
Carcinogenicity of 2,2'-diamino-1,1'-dinaphthyl has been investigated in chronic experiments on LIO rats and CC57 mice. Single doses of 20 mg were given to rats and 1-5 mg--mice. Subcutaneous injections were followed by sarcoma development on injection site in 90% of male rats and 31%--females. Female rats (46%) also revealed multiple benign tumors of the mammary gland. Such tumors alone were detected in females (44%) receiving the agent with feed. All mouse males and 71-100% of females developed hepato- and cholangiocellular tumors as well as hepatic hemangiomas following subcutaneous injection, oral or skin administration. 2,2'-diamino-1,1'-dinaphthyl proved a potent carcinogenic agent; it is suggested that it might metabolize to such carcinogen as 2-naphthylamine.