Thrombolysis with i.v. recombinant human tissue-type plasminogen activator in patients with bypass graft occlusion: a good adjunctive therapeutic mode (preliminary and case reports)
Agresta, F.; Michelet, I.; Boni, V.; Tonietto, G.
Journal of Cardiovascular Surgery 39(5): 551-555
1998
ISSN/ISBN: 0021-9509 PMID: 9833710 Document Number: 497903
Background and methods. The authors report their experience with thrombolytic therapy in seven cases of graft thrombosis managed successfully with low-dose I.V. rt-TPA. In six patients the cause was an anatomical one and so, after the successful lysis, there was enough time to confirm a correct diagnosis and plan the right" and "less extensive" surgical procedure, obviating it in one case with a "functional" cause of thrombosis. Results. No complication directly attributable to rt-TPA infusion occurred, and no systemic fibrinogenolysis was registered in any cases. judging from this experience, I.V. rt-TPA appears safe and effective in patients with graft thrombosis, proving to be a good adjunctive therapeutic mode. Conclusions. Further studies are needed do delineate more clearly safe indication and the validity of this method.