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Modulation of the antiarrhythmic effect by endogenous opioids during adaptation to hypoxia in rats

Lishmanov, I.B.; Uskina, E.V.; Krylatov, A.V.; Kondrat'ev, B.I.; Ugdyzhekova, D.S.; Maslov, L.N.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 84(4): 363-372

1998

ISSN/ISBN: 0869-8139
PMID: 9742615
Document Number: 497797
Adaptation of rats to hypoxia increased the heart resistance against arrhythmogenic effects. The Met-enkephaline-Arg6-Phe7 contant increased in the hypothalamus of the adapted animals. The blockers of mu- and delta-opioid receptors reduced the antiarrhythmic effect of the adaptation, whereas chi-receptor inhibitor, nor-binaltorphimine, completely abolished it. The findings suggest the antiarrhythmic effect depends on an increase of the endogenous opioids level and modulated effect of these peptides upon autonomous nervous system.

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