The syndrome of inappropriate TSH secretion of neoplastic origin (NIST)
Grzywa, M.; Wis, J.M.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 5(26): 101-103
1998
ISSN/ISBN: 1426-9686 PMID: 10101468 Document Number: 497667
The authors present clinical features, diagnostic approach and treatment of inappropriate TSH secretion syndrome. To data above 80 cases of this syndrome have been described. The main clinical features are thyrotoxicosis and vascular goiter present in the patient with pituitary adenoma. High concentrations of free thyroid hormones coexist with elevated TSH serum level. In some cases hyperproduction of other anterior lobe pituitary hormones was found. The molar ratio alpha subunit to TSH exceeds 1.0. In the management of inappropriate TSH secretion syndrome hypophysectomy, irradiation and long-acting somatostatin analog octreotide are applied.