Liposome encapsulation of cystostatic drugs and starch microspheres improve tumor targeting in locoregional therapy. An animal experiment study of CC 531 liver tumor
Berger, G.; Reszka, R.; Pohlen, U.; Jung, M.; Lucas, S.; Buhr, H.J.
Langenbecks Archiv für Chirurgie. Suppl. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 115(Suppl I): 693-697
1998
ISSN/ISBN: 0942-2854 PMID: 14518343 Document Number: 493878
Systemic adjuvant chemotherapy achieves unsatisfactory results for inoperable liver tumors and metastases. Various clinical studies have shown that locoregional chemotherapy increased the survival rate by a few months. The aim of this study was to investigate tumor targeting of the most frequently used cytostatic 5-fluouracil by modifying systemic and locoregional therapy by liposome encapsulation. The tumor concentration of 5-FU encapsulated in SUV-PEG liposomes increases by a factor of 27 in systemic therapy and a factor of 90 in locoregional therapy. The tumor concentration of 5-FU increases by a factor of 8000, if the blood flow is additionally slowed by starch microspheres (Spherex) during locoregional therapy with liposome-encapsulated 5-FU.