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Study on the relationship between deoxyribonucleoside triphosphate (dNTP) pools and cell transformation

Lei, H.; Li, Z.; Xie, D.; Liu, B.

Wei Sheng Yan Jiu 27(2): 73-76

1998

ISSN/ISBN: 1000-8020
PMID: 10682608
Document Number: 493810
Deoxyribonucleoside triphosphate (dNTP) pools were measured in normal BALB/c3T3 cells, transformation-treated cells and transformed cells with reverse-phase HPLC. The fluctuation of dNTP pools was similar after cells were treated with alkylating mutagens glycidyl methacrylate (GMA) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The gap between (dGTP + dATP) pools and (dTTP + dCTP) pools was greatly intensified. The measurements also indicated that the dNTP pools in transformed cells were quite different from those in normal cells. The results suggest that dNTP pools may play an important role in cell transformation.

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