A controlled clinical trial of chloramphenicol in chloramphenicol-resistant typhoid fever
Calderón, E.; Gilman, R.H.; Snyder, M.J.; Vázquez, V.; Barreto, D.G.; Legorreta, J.; Rodríguez, R.; Martínez, E.; Hornick, R.B.; Woodward, T.E.
Revista Latinoamericana de Microbiologia 16(3): 131-136
1974
ISSN/ISBN: 0187-4640 PMID: 4610682 Document Number: 4920
A randomized clinical trial of chloramphenicol and ampicillin in the treatment of disease caused by chloramphenicol-resistant S. typhi was performed in Mexico City in August-September 1972. The chloramphenicol treated group did hot respond as well as the ampicillin treated group in any characteristic examined: duration of fever, duration of positive blood and stool cultures, number of clinical failures and the complication rate. Duration of bacteremia was a sensitive indicator of antibiotic efficacy. In regions where S. typhi resistant to chloramphenicol are common, patients suspected of having typhoid should be treated initially with either ampicillin or trimethoprim sulfamethoxazole until the results of antibiotic sensitivity testing are available.
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