The comparison of primordial germ cell populations in embryos of KE and CBA inbred strains of mice
Wabik-Sliz, B.; Paczuska, I.; Wiśniewska, A.; Lenartowicz, M.
Folia Histochemica et Cytobiologica 36(2): 81-85
1998
ISSN/ISBN: 0239-8508 PMID: 9606622 Document Number: 491810
The changes in primordial germ cell (PGC) populations were compared in embryos of two inbred strains of mice-KE and CBA/Kw on 11, 12, 13 and 14 day of foetal life. The number of PGCs did not differ in 11-day embryos of both strains. In 12-day CBA/Kw embryos the proliferation rate of PGCs was higher and the number of PGC was significantly higher than in 12-day KE embryos. However, on subsequent days the PGC proliferation rate decreased in CBA/Kw but rapidly increased in KE embryos, leading to significantly higher number of PGCs in 14-day KE embryos. These differences in proliferation rate between KE and CBA/Kw PGCs can be regarded as the reason of strong selection against CBA/Kw derived gametes observed in KE<-->CBA aggregation chimaeras.