Expression of nitric oxide synthase in squamous cell carcinoma of tongue and its prognosis
Chen, W.; Li, H.; Pan, C.
Zhonghua Kou Qiang Yi Xue Za Zhi 33(3): 152-154
1998
ISSN/ISBN: 1002-0098 PMID: 11774417 Document Number: 491188
To study the expression of nitric oxide synthase (NOS) in squamous cell carcinoma of tongue and its prognosis. The NOSI, NOSII and NOSIII of 55 cases of squamous cell carcinoma of tongue were detected by immunohistochemistry. The expressive rates of NOSI, NOSII and NOSIII were 30.9%, 40.0% and 38.2% respectively. There were significant differences between the patients with and without neck nodal metastasis, and between the patients survival more than 5 years and less than 5 years (P < 0.01), There were differences between G1, G2 and G3 and the clinical stages in NOSII (P < 0.05). The expression of the NOSI, NOSII and NOSIII in squamous cell carcinoma of tongue is raleted to its prognosis and the NOSII plays a more important role in growth, differentiation, metastatic capability and prognosis of the tumor.