Peripheral Primitive Neuroectodermal Tumor (Peripheral Neuroepithelioma) in a Dog
Hosokawa, S.; Suzuki, S.; Hibino, N.; Fukuta, T.; Imai, T.; Hayakawa, K.; Nakanowatari, J.; Sagami, F.
Contemporary Topics in Laboratory Animal Science 37(1): 66-69
1998
ISSN/ISBN: 1060-0558 PMID: 12456182 Document Number: 490951
A peripherally located primitive neuroectodermal tumor (peripheral PNET) originating in subcutaneous tissues was observed in an adult Beagle. The highly aggressive tumor spread rapidly and metastasized to various organs. The neoplasm was diagnosed as a peripheral PNET on the basis of morphologic and immunohistochemical characteristics such as small round tumor cells, rosette formations, many interdigitating cytoplasmic processes, neurosecretory granules and microtubules, and positive immunohistochemical reactions to neurogenic markers. We describe here the first report of a peripheral PNET in a dog. Peripheral PNET should be included in the list of differential diagnoses for soft-tissue tumors in dogs.