Dent's disease--the hypercalciuric variant of Fanconi's syndrome
Kabícek, P.; Bayer, M.
Sbornik Lekarsky 99(1): 21-24
1998
ISSN/ISBN: 0036-5327 PMID: 9748795 Document Number: 490593
Dent's disease is a rare type of proximal renal tubular defect characterized by hypercalciuria, low-molecular-weight (LMW) proteinuria, nephrocalcinosis and slowly progressive renal failure, short stature and osteopenia in children with clinical symptoms of rickets. This "hypercalciuric rickets" was originally described by Charles Dent and Max Friedman in 1964 [1]. The disease is probably linked to the X chromosome so that males are much more severely affected than females.