Chondrocalcinosis is a feature of Gitelman's variant of Bartter's syndrome. a new look at the hypomagnesemia associated with calcium pyrophosphate dihydrate crystal deposition disease
Punzi, L.; Calò, L.; Schiavon, F.; Pianon, M.; Rosada, M.; Todesco, S.
Revue du Rhumatisme 65(10): 571-574
1998
ISSN/ISBN: 1169-8446 PMID: 9809361 Document Number: 485398
The occurrence of chondrocalcinosis in patients with Bartter's syndrome has been reported as a typical example of hypomagnesemia-associated calcium pyrophosphate dihydrate crystal (CPPD) deposition disease. However, hypomagnesemia is a feature of Gitelman's variant of Bartter's syndrome, whereas serum magnesium levels are normal in Bartter's syndrome strictly speaking. We managed four patients with chondrocalcinosis and hypomagnesemia who met criteria for Gitelman's disease, including hypomagnesemia, hypokalemia with normal or high urinary potassium excretion, hypocalciuria, and normal blood pressure. Based on our experience with these patients, we argue that many cases of chondrocalcinosis and hypomagnesemia ascribed in previously published articles to Bartter's syndrome were due to Gitelman's syndrome.