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The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia

Saĭfutdinov, R.R.; Khazanov, V.A.

Eksperimental'naia i Klinicheskaia Farmakologiia 61(5): 27-29

1998

ISSN/ISBN: 0869-2092
PMID: 9854629
Document Number: 489434
Oxidative phosphorylation in the mitochondria of rat brain in normobaric hypercapnic hypoxia and preventive administration of Scutellaria baicalensis extract was studied by polarography. Hypoxia causes diminution of energy of the rat brain mitochondria with separation of oxidative phosphorylation and inhibition of the reactions of rapid metabolic cluster of Krebs' cycle. Scutellaria baicalensis extract prevents diminution of energy of the brain mitochondria in hypoxia, inhibits restriction of succinate dependent energy production, and preserves intactness of the mitochondrial membranes.

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