Regulation of megakaryopoiesis and thrombopoiesis by thrombopoietin
Oda, A.; Ikeda, Y.
Rinsho Byori. Japanese Journal of Clinical Pathology 46(5): 430-434
1998
ISSN/ISBN: 0047-1860 PMID: 9627493 Document Number: 489167
Thrombopoietin (TPO) is a major hematopoietic growth factor which regulates the production of megakaryocytes and platelets. Recent cloning of its c-DNA and availability of recombinant TPO have enabled us to examine the biological effects of TPO in various systems, including human platelets. In this review, we briefly describe the recent progresses made in the studies of TPO and its cognate receptor, c-Mp1.