New aspects of megakaryopoiesis
Geissler, D.; Peschel, C.; Konwalinka, G.
Wiener Klinische Wochenschrift 95(19): 685-688
1983
ISSN/ISBN: 0043-5325 PMID: 6666157 Document Number: 199916
Like erythro- and granulopoiesis megakaryocytopoiesis (MK poiesis) is controlled by specific feed-back mechanisms. Platelet production has been found to be regulated predominantly by the number or mass of circulating platelets. Our present understanding of MK poiesis is based on data from 3 major experimental areas, which are individually discussed in this paper. In vivo experiments on thrombocytotic or thrombocytopenic mice. Radioisotopic assays for thrombopoietin determination. Investigation by in vitro culture methods of megakaryocyte colony-forming precursor cells (CFU-M).
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