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Cushing with transition from pituitary to adrenal origin. Study with SPECT scintigraphy of the adrenal cortex with norcholesterol-i 131 in a case

Araya, V.; Jofré, J.; Hidalgo, P.; Massardo, T.; Amat, J.; Pumarino, H.

Revista Medica de Chile 126(9): 1103-1107

1998

ISSN/ISBN: 0034-9887
PMID: 9922515
Document Number: 487249
The case of a 49 yr old alcoholic women with clinical and laboratory findings that suggested a Cushing syndrome is presented. The functional tests showed cortisol suppression greater than 50% of the basal value with 8 mg of dexamethasone and no response in the combined dexamethasone/desmopressin test. Pituitary Nuclear Magnetic Resonance (NMR) was negative, Abdominal Computed Axial Tomography suggested hyperplastic adrenal glands; adrenal nodules were not found in the NMR. Pituitary or hipothalamic Cushing with secondary autonomous micronodular adrenal hyperplasia was suspected. Norcholesterol-I131 SPECT scintigraphy under dexamethasone suppression demonstrated a functional adrenal hyperplasia which was hystologically confirmed.

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